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KMID : 1144820220280040276
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대한의생명과학회지
2022 Volume.28 No. 4 p.276 ~ p.283
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Saccharina japonica Attenuates the Allergic Inflammation in vivo and in vitro
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Lee Soo-Yeon
Kim Su-Jin
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Abstract
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Saccharina japonica (SJ), a brown algae, exerts various pharmacological effects, including anti-oxidant, immune-modulating and anti-cancer properties. This study aimed to determine the pharmacological mechanism of SJ on atopic dermatitis in vivo and in vitro. We investigated the pharmacological effects of SJ on 2, 4-dinitrochlrobenzene (DNCB)-induced atopic dermatitis clinical symptoms in mice. Additionally, we evaluated the effects of SJ on the inflammatory cytokine production and nuclear factor-κB (NF-κB) activation in HaCaT cells. The findings of this study demonstrated that SJ reduced the clinical symptoms of atopic dermatitis, such as skin dryness, erythema and eczematous, and serum histamine and IgE level in DNCB-induced atopic dermatitis model. Additionally, SJ inhibited the NF-κB activation in atopic dermatitis-like skin lesion and HaCaT cells. Collectively, this result suggests that SJ could be used as a therapeutic agent for skin inflammation, including atopic dermatitis.
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KEYWORD
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Saccharina japonica, Atopic dermatitis, Nuclear factor-κB, HaCaT cells
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